Table of ContentsIntroductionHistorical BackgroundBasic Renal Physiology and the Role of the Loop of HenleOverview of Nephron SegmentsThick Ascending Limb (TAL) FunctionConsequences of TAL InhibitionChemistry and Classification of Loop DiureticsMechanism of ActionNa⁺/K⁺/2Cl⁻ Cotransporter InhibitionSecondary EffectsPharmacodynamicsDose-Response RelationshipPotency VariationsCeiling EffectPharmacokinetics of Key Loop DiureticsFurosemideBumetanideTorsemideEthacrynic AcidClinical IndicationsDosage and AdministrationDosing PrinciplesConversion & EquivalenceContinuous InfusionsAdverse EffectsDrug InteractionsNSAIDsACE Inhibitors and ARBsAminoglycosidesLithiumCorticosteroidsDigoxinLoop Diuretic … Continue reading Pharmacology of Loop Diuretics