Factors Affecting Oral Drug Absorption and its Bioavailability

Table of ContentsI. Physical Properties:1. Physical state:2. Lipid or water solubility:II. Dosage Forms:1. Particle size:2. Disintegration time and dissolution rate:3. Formulation:III. Physiological Factors:1. Ionisation:2. pH of the GI fluid and the blood:3. GI transit time:4. Enterohepatic cycling:5. Area of the absorbing surface and local circulation:6. First pass elimination:7. Presence of other agents:IV. Pharmacogenetic factors:V. Disease … Continue reading Factors Affecting Oral Drug Absorption and its Bioavailability