Table of ContentsWhat clinical pharmacokinetics does in practiceCore Concepts and ParametersADME and the exposure–response paradigmClearance, volume, and half-lifeBioavailability and first-pass metabolismDeterminants of AbsorptionPhysicochemical and formulation factorsFood effects and first-pass extractionDistribution and Protein BindingPlasma protein binding and clinical implicationsTissue distribution and special compartmentsMetabolism, Excretion, and TransportersMetabolic pathwaysRenal and biliary excretionTransporters and clinically relevant DDIsLinear, Nonlinear, and … Continue reading Clinical Pharmacokinetics: From Principles to Individualized Dosing