Table of ContentsINTRODUCTIONCHEMICAL STRUCTURE AND CLASSIFICATIONBasic Chemical StructureExamples of Clinically Relevant AminoglycosidesClassification ApproachMECHANISM OF ACTION Targeting Bacterial Protein SynthesisConcentration-Dependent Killing and Post-Antibiotic EffectPHARMACOKINETICS AbsorptionDistributionMetabolismExcretionImplications for DosingPHARMACODYNAMICS Concentration-Dependent Bactericidal ActivityPost-Antibiotic Effect (PAE)Synergy with Other AntibioticsSPECTRUM OF ACTIVITY Gram-Negative BacteriaGram-Positive BacteriaAtypical PathogensMycobacteriaTHERAPEUTIC USES Serious Gram-Negative InfectionsCombination Therapy for Gram-Positive InfectionsTuberculosis and Mycobacterial DiseasesTopical/Local UsesInhaled FormulationsDOSING AND ADMINISTRATION … Continue reading Pharmacology of Aminoglycoside antibiotics